期刊
INTEGRATIVE BIOLOGY
卷 7, 期 8, 页码 846-858出版社
OXFORD UNIV PRESS
DOI: 10.1039/c5ib00083a
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资金
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
- CONICYT
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
- NNF Center for Biosustainability [Yeast Cell Factories] Funding Source: researchfish
Genome scale models (GEMs) have enabled remarkable advances in systems biology, acting as functional databases of metabolism, and as scaffolds for the contextualization of high-throughput data. In the case of Saccharomyces cerevisiae (budding yeast), several GEMs have been published and are currently used for metabolic engineering and elucidating biological interactions. Here we review the history of yeast's GEMs, focusing on recent developments. We study how these models are typically evaluated, using both descriptive and predictive metrics. Additionally, we analyze the different ways in which all levels of omics data (from gene expression to flux) have been integrated in yeast GEMs. Relevant conclusions and current challenges for both GEM evaluation and omic integration are highlighted.
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