期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 64, 期 12, 页码 1277-1291出版社
ELSEVIER
DOI: 10.1016/j.addr.2012.03.014
关键词
rhBMPs; Regenerative medicine; Spinal surgery; Bone fracture; Oral surgery; Bone tissue engineering; Drug delivery
资金
- National Science Foundation
- Jo-Anne Smith, MD research and education foundation
- [NSF-EFRI 0736002]
- [NIH-R21 AR060480]
- Emerging Frontiers & Multidisciplinary Activities
- Directorate For Engineering [0902969] Funding Source: National Science Foundation
Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs) have been the most extensively studied and widely used osteoinductive agents for clinical bone repair. Since rhBMP-2 and rhBMP-7 were cleared by the U.S. Food and Drug Administration for certain clinical uses, millions of patients worldwide have been treated with rhBMPs for various musculoskeletal disorders. Current clinical applications include treatment of long bone fracture non-unions, spinal surgeries, and oral maxillofacial surgeries. Considering the growing number of recent publications related to clincal research of rhBMPs, there exists enormous promise for these proteins to be used in bone regenerative medicine. The authors take this opportunity to review the rhBMP literature paying specific attention to the current applications of rhBMPs in bone repair and spine surgery. The prospective future of rhBMPs delivered in combination with tissue engineered scaffolds is also reviewed. (C) 2012 Elsevier B.V. All rights reserved.
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