期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 64, 期 12, 页码 1090-1110出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.01.008
关键词
Biomaterial; Calcium phosphate cement; Ceramic matrix; Bioceramic; Hydroxyapatite; Bone regeneration; Protein; Growth factor; Ions; Antibiotic
资金
- Spanish Ministry of Science and Innovation in the MAT project
- Juan de la Cierva fellowship
- prize ICREA Academia for excellence in research
- Generalitat de Catalunya
Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions. (c) 2012 Elsevier B.V. All rights reserved.
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