期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 63, 期 14-15, 页码 1361-1370出版社
ELSEVIER
DOI: 10.1016/j.addr.2011.10.002
关键词
Aptamers; Nanomaterials; Biosensors; Drug delivery
资金
- National Natural Science Foundation of China [20975034]
- National Key Scientific Program of China [2011CB911001, 2011CB911003]
- National Institutes of Health [GM066137, GM079359, CA133086]
- Interdisciplinary Center for Biotechnology Research (ICBR) at the University of Florida
The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cellspecific recognition, high-efficiency separation, and targeted drug delivery. (C) 2011 Elsevier B.V. All rights reserved.
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