期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 62, 期 15, 页码 1479-1485出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2010.04.002
关键词
Hydrogel; Tissue engineering; Cartilage; Liver; Elastin; Crosslinking; Vascular graft
资金
- NIH [R01EB02263, P01AR50245, R01GM061232]
- North Carolina Biotechnology Center
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering. (C) 2010 Elsevier B.V. All rights reserved.
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