期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 13, 页码 1203-1213出版社
ELSEVIER
DOI: 10.1016/j.addr.2009.05.006
关键词
Polymer-conjugate; Polymer therapeutics; Nanomedicine; Targeted drug delivery; Combination therapy; Cancer
资金
- Spanish MICINN [CrQ2007-60601]
The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer-drug conjugates are well established for the delivery of a single therapeutic agent, but only in very recent years their use has been extended to the delivery of multi-agent therapy. These early studies revealed the therapeutic potential of this application but raised new challenges (namely, drug loading and drugs ratio, characterisation, and development of suitable carriers) that need to be addressed for a successful optimisation of the system towards clinical applications. (C) 2009 Elsevier B.V. All rights reserved.
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