期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 2, 页码 115-127出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2008.09.011
关键词
Respiratory gene therapy; NANs; Nucleic acid containing nanoparticles; Mucus Alveolar fluid
资金
- FWO (Fund for Scientific Research-Flanders) [G.0310.02, G.0320.04]
- Ghent University
Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid. This must allow the reader to gain insights into the mechanisms by which respiratory secretions may impede the gene transfer efficiency of nucleic acid containing nanoparticles (NANs). Subsequently, we will summarize the efforts that have been done to understand the barrier properties of respiratory mucus and alveolar fluid towards the respiratory delivery of therapeutic nucleic acids. Finally, new and current strategies that can overcome the inhibitory effects of respiratory secretions are discussed. (C) 2008 Elsevier B.V. All rights reserved.
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