期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 12, 页码 1065-1083出版社
ELSEVIER
DOI: 10.1016/j.addr.2009.07.008
关键词
Electrospun nanofiber; Bone tissue engineering; Biomimetic matrix; Bone bioactivity; 3D scaffolding
资金
- MOST [R01-2007-000-20183-0]
- MOEHRD [KRF-2007-314-E00183]
- National Research Foundation of Korea [전06A1112, 2007-0054782, 314-2007-1-E00183] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nanofibrous materials produced by electrospinning processes have attracted considerable interest in tissue regeneration, including bone reconstruction. A range of novel materials and processing tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore degenerated functions of the bone. Degradable polymers, bioactive inorganics and their nanocomposites/hybrids nanofibers with suitable mechanical properties and bone bioactivity for osteoblasts and progenitor/stem cells have been produced. The surface functionalization with apatite minerals and proteins/peptides as well as drug encapsulation within the nanofibers is a promising strategy for achieving therapeutic functions with nanofibrous materials. Recent attempts to endow a 3D scaffolding technique to the electrospinning regime have shown some promise for engineering 3D tissue constructs. With the improvement in knowledge and techniques of bone-targeted nanofibrous matrices, bone tissue engineering is expected to be realized in the near future. (c) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据