期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 6, 页码 457-466出版社
ELSEVIER
DOI: 10.1016/j.addr.2009.03.010
关键词
Nanomaterial; Toxicity; In vivo; Dendrimer; Carbon nanotube; Quantum dot; Gold nanoparticle; Analysis
资金
- NCI NIH HHS [R21 CA132033, R21 CA132033-01] Funding Source: Medline
- NCRR NIH HHS [P20 RR015563-086738, P20 RR016443, P20 RR015563, P20 RR015563-096215] Funding Source: Medline
- NIAMS NIH HHS [R03 AR054035] Funding Source: Medline
It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposures to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed. (C) 2009 Elsevier B.V. All rights reserved.
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