期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 2, 页码 101-114出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2008.09.006
关键词
Mass transport; Diffusion in gel; Imaging; Mucosa; Drug delivery; Particles
资金
- NIBIB NIH HHS [R01 EB000487-16, R01 EB000487-14, R01 EB000487, R01 EB000487-17, R01 EB000487-15, R01 EB000487-13] Funding Source: Medline
- NIGMS NIH HHS [R01 GM043873-12, R01 GM043873-11, R01 GM043873-10] Funding Source: Medline
The rate of molecular transport through the mucus gel can be an important determinant of efficacy for therapeutic agents delivered by oral, intranasal, intravaginal/rectal, and intraocular routes. Transport through mucus can be described by mathematical models based on principles of physical chemistry and known characteristics of the mucus gel, its constituents, and of the drug itself. In this paper, we review mathematical models of molecular diffusion in mucus, as well as the techniques commonly used to measure diffusion of solutes in the mucus gel, mucus gel mimics, and mucosal epithelia. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据