期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 9, 页码 710-720出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2009.04.001
关键词
Polycations; Nanoparticles; Polyplexes; RNA interference; siRNA; In vivo; Intravenous; Bioresponsive; Extracellular; Intracellular
RNAi-based therapies are dependent on extracellular and intracellular delivery of RNA molecules for enabling target interaction. Polycation-based nanoparticles (or polyplexes) formed by self-assembly with RNA can be used to modulate pharmacokinetics and intracellular trafficking to improve the therapeutic efficacy of RNAi-based therapeutics. This review describes the application of polyplexes for extracellular and intracellular delivery of synthetic RNA molecules. Focus is given to routes of administration and silencing effects in animal disease models. The inclusion of functional components into the nanoparticle for controlling cellular trafficking and RNA release is discussed. This work highlights the versatile nature of polycation-based nanoparticles to fulfil the delivery requirements for RNA molecules with flexibility in design to evolve alongside an expanding repertoire of RNAi-based drugs. (C) 2009 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据