期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 14, 页码 1283-1298出版社
ELSEVIER
DOI: 10.1016/j.addr.2009.07.015
关键词
Mitochondria; Energy-redox axis; Lipoic acid; Thiol/disulfide exchange; Alzheimer's disease; Aging
资金
- NIH [RO1-AG16718, AA016911]
- TRDRP [16RT-0186]
- Office of the Provost at the University of Southern California
- DH
Decrease in mitochondrial energy-transducing capacity is a feature of the aging process that accompanies redox alterations, such as increased generation of mitochondrial oxidants, altered GSH status, and increased protein oxidation. The decrease in mitochondrial energy-transducing capacity and altered redox status should be viewed as a concerted process that embodies the mitochondrial energy-redox axis and is linked through various mechanisms including: (a) an inter-convertible reducing equivalents pool (i.e., NAD(P)(+)/NAD(P)H) and (b) redox-mediated protein post-translational modifications involved in energy metabolism. The energy-redox axis provides the rationale for therapeutic approaches targeted to each or both component(s) of the axis that effectively preserves or improve mitochondrial function and that have implications for aging and age-related neurodegenerative disorders. (C) 2009 Elsevier B.V. All rights reserved.
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