期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 61, 期 14, 页码 1343-1352出版社
ELSEVIER
DOI: 10.1016/j.addr.2009.06.007
关键词
Lipoic acid; Acetyl-L-carnitine; Hydroxytyrosol; (-)-Epigallocatechin gallate (EGCG); B vitamins; Mitochondrial nutrients; Reactive oxygen species
资金
- Pujiang Talent Award [05PG1 4104]
- Shanghai Science and Technology Committee, Shanghai, China [074319105]
- National Natural Science Foundation of China [30871002]
- DSM Nutritional Product, Switzerland
- UC Davis Center for Human and Nutrition [CHNR08-318]
Insulin resistance is an important feature of type 2 diabetes and obesity. The underlying mechanisms of insulin resistance are still unclear and may involve pathological changes in multiple tissues. Mitochondrial dysfunction, including mitochondrial loss and over-production of oxidants, has been suggested to be involved in the development of insulin resistance. Increasing evidence suggests that targeting mitochondria to protect mitochondrial function as a unique measure, i.e. mitochondrial medicine, could prevent and ameliorate various diseases associated with mitochondrial dysfunction. In this review, we have summarized recent progress in pharmaceutical and nutritional studies of drugs and nutrients to targeting mitochondria by stimulating mitochondrial metabolism (biogenesis and degradation) to improve mitochondrial function and decrease oxidative stress for preventing and ameliorating insulin resistance. We have focused on nutrients from natural sources to stimulating mitochondrial biogenesis in cellular systems and in animal models. The in vitro and in vivo studies, especially our own work on the effects and mechanisms of mitochondrial targeting nutrients or their combinations, may help us to understand the importance and mechanisms of mitochondrial biogenesis in insulin resistance, and provide hope for developing mitochondria-targeting agents for preventing and treating insulin resistance in type 2 diabetes and obesity. (C) 2009 Elsevier B.V. All rights reserved.
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