期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 60, 期 2, 页码 184-198出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2007.08.041
关键词
biomimetic; tissue engineering; regeneration; polymer scaffold; matrix; biomaterial; nano; controlled release
资金
- NIDCR NIH HHS [R01 DE015384-04, DE017689, R01 DE017689, R21 DE014755-01A1, R01 DE015384, R01 DE015384-03, R01 DE017689-02, R21 DE014755-02, R21 DE014755, R01 DE017689-01A1, DE015384, DE014755] Funding Source: Medline
- NIGMS NIH HHS [R21 GM075840-02, R21 GM075840-01, R21 GM075840, GM075840] Funding Source: Medline
Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or wound healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/wound healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration. (c) 2007 Elsevier B.V All rights reserved.
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