期刊
ADDICTIVE BEHAVIORS
卷 33, 期 1, 页码 41-53出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.addbeh.2007.05.011
关键词
cocaine dependence; subtyping; cluster analysis; heritability; phenotype
资金
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [K24AA013736] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA000326, R01DA012690, R01DA012849, K24DA022288, K24DA015105] Funding Source: NIH RePORTER
- NIAAA NIH HHS [K24 AA13736, K24 AA013736-04, K24 AA013736] Funding Source: Medline
- NIDA NIH HHS [K24 DA022288, K24 DA15105, R01 DA012690, K02 DA000326, K02 DA00326, R01 DA012690-08, R01 DA12690, R01 DA012849-07, K02 DA000326-10, K24 DA015105-05, K24 DA015105, R01 DA12849, R01 DA012849] Funding Source: Medline
Cocaine dependence (CD) is a multifactorial disorder, variable in its manifestations, and heritable. We examined the concurrent validity of homogeneous subgroups of CD as phenotypes for genetic analysis. We applied data reduction methods and an empirical cluster-analytic approach to measures of cocaine use, cocaine-related effects, and cocaine treatment history in 1393 subjects, from 660 small nuclear families. Four of the six clusters that were derived yielded heritability estimates in excess of 0.3. Linkage analysis showed genome-wide significant results for two of the clusters. Here we examine the concurrent validity of the six clusters using a variety of demographic and substance-related measures. In addition to being differentiated by a variety of cocaine-related measures, the clusters differed significantly on measures that were independent of those used to generate the clusters, i.e., demographic features and prevalence rates of co-morbid substance use and psychiatric disorders. These findings support the validity of the methods used to derive homogeneous subgroups of CD subjects and the resulting CD subtypes. Independent replication of these findings would provide further validation of this approach. (c) 2007 Elsevier Ltd. All rights reserved.
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