期刊
ADDICTION BIOLOGY
卷 19, 期 6, 页码 972-974出版社
WILEY-BLACKWELL
DOI: 10.1111/adb.12064
关键词
Cocaine; context-induced relapse; dendritic spines; nucleus accumbens core; synaptic potentiation
资金
- National Institutes of Health [DA033690, DA03906, DA012513, DA015369]
- NATIONAL INSTITUTE ON DRUG ABUSE [R37DA003906, R01DA012513, R01DA003906, P50DA015369, F32DA033690] Funding Source: NIH RePORTER
Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.
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