期刊
ADDICTION BIOLOGY
卷 19, 期 3, 页码 338-342出版社
WILEY
DOI: 10.1111/adb.12015
关键词
muscimol + baclofen; Conditioned cues; hippocampus; relapse; reinstatement; drug environment; heroin self-administration
资金
- National Institute on Drug Abuse (NIH, DHHS)
In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.
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