期刊
ADDICTION BIOLOGY
卷 18, 期 1, 页码 78-87出版社
WILEY-BLACKWELL
DOI: 10.1111/adb.12006
关键词
cocaine; knockout; motor sensitization; oleoylethanolamide; PPARa; reinforcement
资金
- Consejeria de Innovacion, Ciencia y Empresa of the Regional Andalusian government [P07-CTS-03324]
- Red de Trastornos Adictivos RETICS network from the Spanish Health Institute Carlos II [RD06/0001/0000]
- Plan Nacional sobre Drogas [049/2009]
- Andalusian Health Service [SAS 111224]
- Plan Andaluz de Investigacion (Junta de Andalucia) [BIO127]
- Ministerio de Sanidad [2009I039]
- Ministerio de Sanidad RETICS from Instituto Carlos III [RD06/001/002]
- FEDER
- European Fund for Regional Development
- MICINN, Spain
- COFUND/U-Mobility fellowship
- National System of Health (Instituto de Salud Carlos III, Spain [CD08/00203]
Oleoylethanolamide (OEA) is an acylethanolamide that acts as an agonist of nuclear peroxisome proliferator-activated receptor alpha (PPARa) to exert their biological functions, which include the regulation of appetite and metabolism. Increasing evidence also suggests that OEA may participate in the control of reward-related behaviours. However, direct experimental evidence for the role of the OEA-PPARa receptor interaction in drug-mediated behaviours, such as cocaine-induced behavioural phenotypes, is lacking. The present study explored the role of OEA and its receptor PPARa on the psychomotor and rewarding responsiveness to cocaine using behavioural tests indicative of core components of addiction. We found that acute administration of OEA (1, 5 or 20?mg/kg, i.p.) reduced spontaneous locomotor activity and attenuated psychomotor activation induced by cocaine (20?mg/kg) in C57Bl/6 mice. However, PPARa receptor knockout mice showed normal sensitization, although OEA was capable of reducing behavioural sensitization with fewer efficacies. Furthermore, conditioned place preference and reinstatement to cocaine were intact in these mice. Our results indicate that PPARa receptor does not play a critical, if any, role in mediating short- and long-term psychomotor and rewarding responsiveness to cocaine. However, further research is needed for the identification of the targets of OEA for its inhibitory action on cocaine-mediated responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据