期刊
ADDICTION BIOLOGY
卷 17, 期 4, 页码 783-785出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2011.00321.x
关键词
Addiction; alcohol-dependence; glutamate; GRIN2A; NMDA; (GT)n repeat
A variable (GT)n repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subjectcontrol analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 x 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
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