期刊
ADDICTION BIOLOGY
卷 16, 期 4, 页码 620-623出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2011.00337.x
关键词
Alcohol addiction; corticomesolimbic pathway; craving; deep brain stimulation; error-related negativity; nucleus accumbens
资金
- Medtronic AG
- Advanced Neuromodulation Systems Inc.
Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error-related negativity) linked to anterior midcingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.
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