期刊
ADDICTION BIOLOGY
卷 15, 期 1, 页码 96-99出版社
WILEY
DOI: 10.1111/j.1369-1600.2009.00179.x
关键词
Acute administration; cocaine; DNA damage; ecstasy; MDMA; single cell gel (comet) assay
资金
- AFIP
- FAPESP [CEPID 98/14303-3, 09/01030-5, 07/01228-4]
- CNPq
We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins.
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