期刊
ADDICTION BIOLOGY
卷 14, 期 4, 页码 447-456出版社
WILEY
DOI: 10.1111/j.1369-1600.2009.00173.x
关键词
Adolescence; cocaine; CPP; MDMA; mice; reinstatement
资金
- Ministerio de Ciencia e Innovacion, Direccion General de Investigacion [PSI2008-00101/PSIC]
- Instituto de Salud 'Carlos III' (FIS)
- RETICS
- Red de Trastornos Adictivos [RD06/001/0016]
- Generalitat Valenciana
- Conselleria de Educacion [PROMETEO/2009/072]
- Agencia Valenciana de Salud. Direccion General de Drogodependencias (FEPAD), Spain
Those who take ecstasy are more likely to consume other drugs than non-users with cocaine abuse being reported by 75.5% of high school student MDMA (+/- 3,4-methylenedioxymetamphetamine hydrochloride) users. The aim of this work was to evaluate the effects of exposure during adolescence to MDMA, cocaine or to both drugs on the MDMA-induced conditioned place preference (CPP) in adult mice. Animals received two daily administrations of saline, 10 mg/kg of MDMA, 25 mg/kg of cocaine or 10 mg/kg of MDMA plus 25 mg/kg of cocaine over 3 days (from PD28 to 30). Three weeks after pre-treatment, the MDMA-induced CPP procedure was initiated (PD52). Acquisition of CPP was induced with a sub-threshold dose of MDMA (1.25 mg/kg) only in animals treated during adolescence with MDMA alone. Preference was established in all the groups after conditioning with 10 mg/kg of MDMA, while the time required to achieve extinction was longer in those pre-treated with cocaine or MDMA alone (46 and 28 sessions, respectively). Moreover, preference was reinstated with progressively lower priming doses of MDMA in mice pre-treated with MDMA or cocaine alone. These results demonstrate that early exposure to MDMA or cocaine induces long-lasting changes that last until adulthood and modify the response of animals to MDMA.
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