4.6 Article

Early age of alcohol initiation is not the cause of alcohol use disorders in adulthood, but is a major indicator of genetic risk. A population-based twin study

期刊

ADDICTION
卷 109, 期 11, 页码 1824-1832

出版社

WILEY
DOI: 10.1111/add.12620

关键词

Alcohol abuse; alcohol dependence; alcohol use; alcohol use disorders; causality; confounding factors; cohort studies; genetics; sex; twin study

资金

  1. National Institutes of Health [MH-068643]
  2. Norwegian Research Council [190509]
  3. Norwegian Foundation for Health and Rehabilitation
  4. Norwegian Council for Mental Health
  5. European Commission [QLG2-CT-2002-01254]

向作者/读者索取更多资源

Background and aimsAn early age of alcohol initiation (AAI) is associated with and has been hypothesized to be a cause of alcohol use disorders (AUD) in adulthood. Results from twin studies, however, indicate that AAI is an indicator of risk for AUD. We aimed to test a causal hypothesis versus a risk indicator hypothesis for the relationship between early AAI and AUD. DesignA population-based twin study using biometric twin modelling. SettingNorway. ParticipantsA population-based sample of 1336 Norwegian twins. MeasurementsLife-time DSM-IV AUDs were assessed by structured clinical interview and AAI by questionnaire. FindingsThe risk indicator model in which the association between AAI and AUD was explained by common vulnerability was the best fitted to the data. The heritability was 37% [95% confidence interval (CI)=21%, 53%] for AAI and 62% (95% CI=51%, 73%) for AUD. Genetic risk for AAI accounted for 44% (95% CI=17%, 71%) of the total genetic risk for AUD and the correlation between genetic factors for AAI and AUD was -0.66 (95%CI -0.87, -0.46). Individual-specific environmental risk for AAI explained only 1% (95% CI=0%, 3%) of the risk for AUD. Shared environmental factors did not influence AUD, but accounted for 25% (95% CI=7%, 35%) of the variance in AAI. ConclusionsThe association between early age of alcohol initiation and alcohol use disorders in later life does not reflect a causal relationship, but is due almost entirely to common genetic risk factors.

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