期刊
ADDICTION
卷 108, 期 4, 页码 688-698出版社
WILEY
DOI: 10.1111/j.1360-0443.2012.04005.x
关键词
Incidence; opioid analgesics; opioid dependence; pain relief; prevalence; systematic review
资金
- WHO Department of Essential Medicines and Pharmaceutical Policies [E 19-APW-246]
Aims To assess the incidence or prevalence of opioid dependence syndrome in adults (with and without previous history of substance abuse) following treatment with opioid analgesics for pain relief. Methods Medline, Embase, CINHAL and the Cochrane Library were searched up to January 2011. Systematic reviews and primary studies were included if they reported data about incidence or prevalence of opioid dependence syndrome (as defined by DSM-IV or ICD-10) in patients receiving strong opioids (or opioid-type analgesics) for treatment of acute or chronic pain due to any physical condition. The data were abstracted, and the methodological quality was assessed using validated checklists. Results Data were extracted from 17 studies involving a total of 88235 participants. The studies included three systematic reviews, one randomized controlled trial, eight cross-sectional studies and four uncontrolled case series. Most studies included adult patients with chronic non-malignant pain; two also included patients with cancer pain; only one included patients with a previous history of dependence. Incidence ranged from 0 to 24% (median 0.5%); prevalence ranged from 0 to 31% (median 4.5%). Conclusions The available evidence suggests that opioid analgesics for chronic pain conditions are not associated with a major risk for developing dependence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据