期刊
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 67, 期 -, 页码 9-14出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2015.05.016
关键词
Drosophila; Midgut; Intestinal stem cells; Homeostasis; Regeneration; Ageing
资金
- Wellcome Trust Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [1511976] Funding Source: researchfish
Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches. The intestinal epithelium has a remarkable regenerative capacity, which has made it a prime paradigm for the study of stem cell-driven tissue self-renewal. The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms involved in the regulation of tissue homeostasis in the adult Drosophila midgut, with a focus on the role of stem cells in this process. We will also discuss processes involving acute or chronic disruption of normal intestinal homeostasis such as damage-induced regeneration and ageing. (C) 2015 Elsevier Ltd. All rights reserved.
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