期刊
ACTA TROPICA
卷 121, 期 3, 页码 324-332出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2011.12.002
关键词
Malaria; Genomics; Population genetics; Plasmodium falciparum; Plasmodium vivax; International Centers of Excellence for Malaria Research
资金
- MRC [MC_UP_A900_1117] Funding Source: UKRI
- Medical Research Council [MC_UP_A900_1117] Funding Source: researchfish
- Medical Research Council [MC_UP_A900_1117] Funding Source: Medline
- NIAID NIH HHS [U19 AI089696, U19 AI089696-01] Funding Source: Medline
Success of the global research agenda toward eradication of malaria will depend on development of new tools, including drugs, vaccines, insecticides and diagnostics. Genomic information, now available for the malaria parasites, their mosquito vectors, and human host, can be leveraged to both develop these tools and monitor their effectiveness. Although knowledge of genomic sequences for the malaria parasites, Plasmodium falciparum and Plasmodium vivax, have helped advance our understanding of malaria biology, simply knowing this sequence information has not yielded a plethora of new interventions to reduce the burden of malaria. Here we review and provide specific examples of how genomic information has increased our knowledge of parasite biology, focusing on P. falciparum malaria. We then discuss how population genetics can be applied toward the epidemiological and transmission-related goals outlined by the International Centers of Excellence for Malaria Research groups recently established by the National Institutes of Health. Finally, we propose genomics is a research area that can promote coordination and collaboration between various ICEMR groups, and that working together as a community can significantly advance the value of this information toward reduction of the global malaria burden. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据