期刊
ACTA TROPICA
卷 107, 期 3, 页码 251-254出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2008.06.009
关键词
Schistosomiasis; Schistosoma japonicum; Kato-Katz technique; Prevalence; Indirect hemagglutination assay (IHA); Diagnosis; Comparative study; China
资金
- National Natural Science Foundation of China [30590374]
- The National High Technology Research and Development Program of China [2006AA02Z402]
From 2001 to 2006, about one-third of the residents aged 5-65 years were selected as the subjects in a schistosome-endemic village located in Jiangxi Province, China. Every I year, all participants were analyzed by the Kato-Katz parasitologic examination and indirect hemagglutination assay (IHA). Statistical analysis of the results showed the k indices ranged from 0.250 to 0.347 between the two methods. Assuming the Kato-Katz results as the gold standard reference, the specificity of the IHA was from 60% to 77%, the positive predictive value of this method was from 19% to 30%, and its sensitivity and negative predictive value were more than 97%. The IHA method is unsuitable for individual screening in endemic community with relatively high prevalence (e.g. with > 10% or more prevalence). A search for a better diagnostic test that can be applied in field situations in China is essential and should be given high priority. (C) 2008 Elsevier B.V. All rights reserved.
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