期刊
ACTA RADIOLOGICA
卷 51, 期 7, 页码 751-767出版社
SAGE PUBLICATIONS LTD
DOI: 10.3109/02841851.2010.491091
关键词
MRI; magnetic resonance imaging; molecular imaging; comparative studies
资金
- NIH, National Cancer Institute, Center for Cancer Research
- NATIONAL CANCER INSTITUTE [ZIASC010051, ZIABC010654] Funding Source: NIH RePORTER
Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on poly-amidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.
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