期刊
NATURE REVIEWS IMMUNOLOGY
卷 10, 期 6, 页码 453-U92出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2784
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资金
- BBSRC [BB/G022607/1] Funding Source: UKRI
- MRC [G0500623, G0900867] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G022607/1] Funding Source: researchfish
- Medical Research Council [G9900991B, G0500623, G0900867] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/G022607/1] Funding Source: Medline
- Medical Research Council [G0900867, G0500623] Funding Source: Medline
- NHLBI NIH HHS [R01 HL096539-02, R01 HL096539] Funding Source: Medline
- NIAID NIH HHS [R01 AI061741, R01 AI049653-10, R01 AI061741-04, R01 AI049653] Funding Source: Medline
When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research.
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