期刊
ACTA PSYCHIATRICA SCANDINAVICA
卷 122, 期 2, 页码 110-117出版社
WILEY
DOI: 10.1111/j.1600-0447.2009.01501.x
关键词
borderline personality disorder; catechol-o-methyltransferase Val158Met polymorphism; females; impulsive aggression; serious life events
类别
资金
- University of Mainz faculty of medicine
Objective: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val158Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). Method: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss-Durkee-Hostility Inventory (BDHI). Results: Childhood sexual abuse was associated with lower BDHI sum score (P = 0.003). In COMT Val158Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (P < 0.05). Conclusion: This study analyzing a specific gene x environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMT Val158Val genotype on the relation between SLEs and impulsive aggression.
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