期刊
ACTA PSYCHIATRICA SCANDINAVICA
卷 118, 期 5, 页码 373-381出版社
WILEY
DOI: 10.1111/j.1600-0447.2008.01245.x
关键词
bipolar disorder; euthymia; lithium; neuropsychological impairment; longitudinal study
类别
资金
- Spanish Ministry of Health
- Instituto de Salud Carlos III
- Centro de Investigacion Biomedica en Salud Mental
- CIBERSAM
- Spanish Ministry of Education and Science
Objective: To investigate the cognitive impairment of a sample of euthymic bipolar patients treated with lithium monotherapy at baseline in a 2-year longitudinal study. Method: Fifteen DSM-IV-TR bipolar out-patients and 15 healthy-matched controls were cognitively assessed twice over a 2-year follow-up. All patients underwent lithium monotherapy on the first evaluation, and they were euthymic in both evaluations. Cognitive assessment was performed by means of a neuropsychological test battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory). Results: Repeated measures multivariate analysis of variance showed that the bipolar disorder group was cognitively impaired in the executive domain, attention and processing speed, and such deficits were maintained over time. Conclusion: Our results showed that executive dysfunction is the main long-term neuropsychological deficit of bipolar disorder. Also, the persistence of these deficits did not seem to be influenced by any clinical or pharmacological variables.
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