期刊
INTERNATIONAL JOURNAL OF MODELING SIMULATION AND SCIENTIFIC COMPUTING
卷 1, 期 2, 页码 157-178出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793962310000122
关键词
Monte-Carlo; Geant4; microdosimetry; nanodosimetry; radiobiology
资金
- CENBG
- France-Japan Particle Physics Laboratory (FJPPL)
- CEA
- High Energy Accelerator Research Organization (KEK) in Japan
The Geant4-DNA project proposes to develop an open-source simulation software based and fully included in the general-purpose Geant4 Monte-Carlo simulation toolkit. The main objective of this software is to simulate biological damages induced by ionizing radiations at the cellular and sub-cellular scale. This project was originally initiated by the European Space Agency for the prediction of the deleterious effects of radiations that may affect astronauts during future long duration space exploration missions. In this paper, the Geant4-DNA collaboration presents an overview of the whole on-going project, including its most recent developments that are available in the Geant4 toolkit since December 2009 (release 9.3), as well as an illustration example simulating the direct irradiation of a biological chromatin fiber. Expected extensions involving several research domains, such as particle physics, chemistry and cellular and molecular biology, within a fully interdisciplinary activity of the Geant4 collaboration are also discussed.
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