期刊
ACTA PHARMACOLOGICA SINICA
卷 34, 期 10, 页码 1284-1291出版社
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2013.127
关键词
hydrogen sulfide; K-ATP channel; calcium channel; TRPA1; NF-kappa B; cytochrome oxidase; antioxidant; H2S donor; H2S-releasing drug; translational medicine
资金
- National Basic Research Program (973 Program) [2010CB 912603]
- National Natural Science Foundation, China [30888002, 30772565]
Hydrogen sulfide (H2S) along with carbon monoxide and nitric oxide is an important signaling molecule that has undergone large numbers of fundamental investigations. H2S is involved in various physiological activities associated with the regulation of homeostasis, vascular contractility, pro-and anti-inflammatory activities, as well as pro-and anti-apoptotic activities etc. However, the actions of H2S are influenced by its concentration, reaction time, and cell/disease types. Therefore, H2S is a signaling molecule without definite effect. The use of existing H2S donors is limited because of the instant release and short lifetime of H2S. Thus, translational medicine involving the sustained and controlled release of H2S is of great value for both scientific and clinical uses. H2S donation can be manipulated by different ways, including where H2S is given, how H2S is donated, or the specific structures of H2S-releasing drugs and H2S donor molecules. This review briefly summarizes recent progress in research on the physiological and pathological functions of H2S and H2S-releasing drugs, and suggests hope for future investigations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据