期刊
ACTA PHARMACOLOGICA SINICA
卷 33, 期 10, 页码 1217-1245出版社
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2012.90
关键词
natural products; phytochemistry; protein tyrosine phosphatase 1B (PTP1B); inhibitor; structure-activity relationship (SAR); type 2 diabetes; obesity
资金
- National Marine 863 Project [2011AA09070102]
- Natural Science Foundation of China [31070310, 40976048, 21021063, 21072204, 81072572]
- SKLDR/SIMM Projects [SIMM1203ZZ-03, SIMM1105KF-04]
- National S&T Major Projects [2011ZX09307-002-03]
- EU 7th Framework Programme-IRSES Project
This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.
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