期刊
ACTA PHARMACOLOGICA SINICA
卷 32, 期 6, 页码 765-780出版社
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2011.57
关键词
ATP-sensitive potassium (K-ATP) channels; channelopathy; neonatal diabetes; congenital hyperinsulinism; glucose homeostasis; diazoxide; sulfonylureas
资金
- Heart and Stroke Foundation of Canada
ATP-sensitive potassium (K-ATP) channels are cell metabolic sensors that couple cell metabolic status to electric activity, thus regulating many cellular functions. In pancreatic beta cells, K-ATP channels modulate insulin secretion in response to fluctuations in plasma glucose level, and play an important role in glucose homeostasis. Recent studies show that gain-of-function and loss-of-function mutations in K-ATP channel subunits cause neonatal diabetes mellitus and congenital hyperinsulinism respectively. These findings lead to significant changes in the diagnosis and treatment for neonatal insulin secretion disorders. This review describes the physiological and pathophysiological functions of K-ATP channels in glucose homeostasis, their specific roles in neonatal diabetes mellitus and congenital hyperinsulinism, as well as future perspectives of K-ATP channels in neonatal diseases.
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