期刊
ACTA PHARMACEUTICA
卷 61, 期 3, 页码 335-342出版社
HRVATSKO FARMACEUTSKO DRUSTOV (HFD)-CROATION PHARMACEUTICAL SOC
DOI: 10.2478/v10007-011-0030-6
关键词
Ganoderma lucidum (Polyporaceae); polysaccharides; anti-inflammatory activity; antitumor activity
资金
- Department of Science and Technology (DST), Government of India, New Delhi
In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg(-1) body mass showed 80.8 and 77.6% reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2% inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg(-1), GLP exhibited 57.6 and 58.2% inhibition in carrageenean-induced and formalin-induced assays, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据