期刊
ACTA PAEDIATRICA
卷 103, 期 10, 页码 1019-1026出版社
WILEY
DOI: 10.1111/apa.12707
关键词
Bronchopulmonary dysplasia; Nitric oxide; Oxidative stress; Premature infants; Pulmonary hypertension
类别
资金
- [R01HL097566]
- [U01HL101456]
Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production. ConclusionStrategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据