期刊
ACTA PAEDIATRICA
卷 103, 期 6, 页码 E243-E250出版社
WILEY
DOI: 10.1111/apa.12615
关键词
Cow's milk protein allergy; (Extensive) hydrolysate; Infant nutrition
类别
资金
- United Pharmaceuticals
AimCow's milk protein allergy (CMPA) is treated using an elimination diet with an extensive protein hydrolysate. We explored whether a thickened or nonthickened version was best for infants with suspected CMPA, which commonly causes regurgitation/vomiting. MethodsDiagnosis of CMPA was based on a positive challenge test. We compared the efficacy of two casein extensive hydrolysates (eCH), a nonthickened version (NT-eCH) and a thickened version (T-eCH), using a symptom-based score covering regurgitation, crying, stool consistency, eczema, urticarial and respiratory symptoms. ResultsA challenge was performed in 52/72 infants with suspected CMPA and was positive in 65.4%. All confirmed CMPA cases tolerated eCH. The symptom-based score decreased significantly in all infants within a month, and the highest reduction was in those with confirmed CMPA. Regurgitation was reduced in all infants (6.43.2-2.8 +/- 2.9, p<0.001), but fell more with the T-eCH (-4.2 +/- 3.2 regurgitations/day vs. -3.0 +/- 4.5, ns), especially in infants with a negative challenge (-3.9 +/- 4.0 vs. -1.9 +/- 3.4, ns). ConclusioneCH fulfilled the criteria for a hypoallergenic formula, and the NT-eCH and T-eCH formulas both reduced CMPA symptoms. The symptom-based score is useful for evaluating how effective dietary treatments are for CMPA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据