期刊
ACTA PAEDIATRICA
卷 101, 期 8, 页码 862-867出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1651-2227.2012.02696.x
关键词
Down syndrome; Immunoglobulins; NKT cells; Regulatory T cells; Respiratory tract infections; T cells
类别
Aim: Children with Down syndrome (DS) experience respiratory tract infections (RTIs) more frequently than healthy children. We investigated whether this is related to different immunological characteristics associated with DS. Methods: The study group consisted of 22 children with DS and 22 of their healthy, age-range matched siblings. Data were collected on infections and hospitalizations because of lower RTIs. Immunoglobulin and IgG subclass levels in blood, as well as lymphocyte and T cell (subset) counts, were determined. Results: The children with DS had a significantly higher frequency of lower RTIs and related hospitalization than their siblings. We also found significantly reduced IgG2 levels as well as significantly lower counts of total lymphocytes, CD4+ T lymphocytes, CD4+ invariant natural killer (iNKT) cells and regulatory T cells in the DS group. Conclusion: In children with DS, reduced levels of IgG2, total lymphocytes, T lymphocytes, iNKT cells and regulatory T cells might contribute to their higher susceptibility to lower RTIs.
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