期刊
ACTA PAEDIATRICA
卷 98, 期 6, 页码 1064-1065出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1651-2227.2009.01270.x
关键词
Arginine; Neonate; Nitric oxide; Pulmonary hypertension; Pyloric stenosis
类别
Nitric oxide (NO) is an important mediator of biological functions. Absence or shortage of NO plays a role in the pathogenesis of both hypertrophic pyloric stenosis and persistent pulmonary hypertension. We present a neonate diagnosed with pulmonary hypertension after birth caused by meconiumaspiration syndrome eventually treated with extracorporal membrane oxygenation followed by hypertrophic pyloric stenosis for which a pyloromyotomy was performed. In conclusion, the association of pulmonary hypertension and pyloric stenosis has not been described before and may be explained by a lowered plasma concentration of arginine leading to deficient NO synthesis in the affected organ systems.
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