期刊
ACTA PAEDIATRICA
卷 97, 期 10, 页码 1465-1469出版社
WILEY
DOI: 10.1111/j.1651-2227.2008.00937.x
关键词
body mass index; children; hexachlorobenzene; obesity; overweight
类别
资金
- Spanish Ministry of Health [FIS97/0588, FIS-00/0021-02]
- Instituto de Salud Carlos III [INMA G03/176]
- Fundacio La Caixa [00/077-00]
- European Comission [QLK4-2000-00263]
Aim: To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources. Methods: Starting from mid 1997, all mothers presenting for antenatal exposure in Menorca were recruited. Subsequently, 482 children were enrolled. HCB was measured in cord blood. Weight and height were measured at birth and at age 6.5 years. Results: Children with HCB levels higher than 1.03 ng/mL in cord blood were 1.14 kg (0.38) heavier and had a higher BMI (beta = 0.80 (0.34)) than children with HCB levels lower than 0.46 ng/mL. No statistically significant associations were found in height. Children in the higher exposure group of HCB had an increased risk of 2.5 and 3.0 of being overweight and obese. Children from normalweight mothers also presented an increased risk of having higher BMI with increasing concentrations of HCB in cord serum. Conclusion: Prenatal exposure to HCB is associated with an increase in BMI and weight at age 6.5 years. Further studies with larger samples and longer follow-up are needed to confirm these results.
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