期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 308, 期 9, 页码 H1126-H1135出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00898.2014
关键词
mineralocorticoid antagonism; low-dose spironolactone; aldosterone; high-fat diet; high-fructose diet; oxidative stress; inflammation; cardiac hypertrophy; myocardial compliance
资金
- American Heart Association Postdoctoral Fellowship [13POST16250010]
- National Institutes of Health [R01-HL073101, RO1-HL107910, K01-AG-041208]
- Department of Veterans Affairs Biomedical Laboratory Research and Development [CDA-2 IK2 BX002030, 0018]
Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western Diet (WD) high in fat, fructose, and sucrose. Female C57BL6J mice were fed a WD with or without Sp (1 mg.kg(-1).day(-1)). After 4 mo on the WD, mice exhibited increased body weight and visceral fat, but similar blood pressures, compared with control diet-fed mice. Sp prevented the development of WD-induced DD, as indicated by decreased isovolumic relaxation time and an improvement in myocardial performance (
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