期刊
ACTA OPHTHALMOLOGICA
卷 90, 期 1, 页码 E31-E37出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1755-3768.2011.02243.x
关键词
diabetic retinopathy; early diabetes; pericyte loss; resveratrol; retina; vascular endothelial growth factor; vascular lesions; vessel leakage
资金
- BK21 program
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A084575]
- MRC of MOST/KOSEF [R13-2005-012-01001-0]
- Korea Health Promotion Institute [A084575] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [R13-2005-012-01001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Purpose: Vessel leakage and loss of pericytes are early signs of diabetic retinopathy (DR), which leads to vision loss. Upregulation of the vascular endothelial growth factor (VEGF) during diabetes plays a key role in mediating these vascular lesions. The aim of this study is to investigate the effects of resveratrol, a natural plant-derived phytoalexin, on vascular damage and VEGF induction in mouse retinas of early diabetes. Methods: Diabetes was induced in C57BL/6 mice by five consecutive-intraperitoneal injections of 55 mg/kg of streptozotocin (STZ). Animals injected with buffer only were used as controls. Beginning 1 month after the fifth injection of STZ or buffer, 20 mg/kg of resveratrol was administered by oral gavage daily for 4 weeks to diabetic and control mice, and all mice were killed 2 months after the injections. We assessed vessel leakage, pericyte loss and VEGF protein expression in mouse retinas of 2-month diabetes compared with controls with or without resveratrol treatment. Results: Diabetes led to increase vessel leakage, pericyte loss and VEGF protein level in the mouse retinas compared with controls; however, these changes were effectively blocked by resveratrol treatment. Conclusion: Our data suggest that resveratrol is effective to decrease vascular lesions and VEGF induction in mouse retinas of early diabetes.
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