期刊
JOURNAL OF ABNORMAL PSYCHOLOGY
卷 119, 期 3, 页码 604-609出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0019709
关键词
psychopathic tendencies; 5-HTT; serotonin; socioeconomic status
资金
- NIDA NIH HHS [R01 DA018647-04, R01 DA018647-03, DA18647, R01 DA018647-01A1S1, R01 DA018647, R01 DA018647-01A1, R01 DA018647-02, R01 DA018647-05S1, R01 DA018647-02S1, R01 DA018647-04S1, R01 DA018647-05] Funding Source: Medline
- NIMH NIH HHS [F31 MH086178-01, F31 MH086178] Funding Source: Medline
Although prior research has examined the genetic correlates of antisocial behavior, molecular genetics influences on psychopathic traits remain largely unknown. Consequently, we investigated the influence of polymorphic variation at the serotonin transporter protein gene (SLC6A4) and socioeconomic resources (SES) on psychopathic traits in youth across two distinct samples in two separate studies. In Study 1, a main effect of serotonin transporter (5-HTTLPR) genotype was associated with the impulsivity dimension of psychopathy. That is, individuals homozygous for the short allele evidenced more impulsivity than did those homozygous for the long allele. In contrast, a gene environment interaction was associated with the callous-unemotional and narcissistic features of psychopathy. Callous-unemotional and narcissistic traits increased as SES decreased only among youths with the homozygous-long (l/1) genotype, a novel finding replicated and extended in Study 2. These studies provide preliminary results that the l/1 genotype confers risk for the emotional deficits and predatory interpersonal traits associated with psychopathy among youths raised in disadvantaged environments.
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