期刊
CONSCIOUSNESS AND COGNITION
卷 19, 期 3, 页码 816-828出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.concog.2010.06.023
关键词
ROC; Recollection; Familiarity; Episodic memory; Hippocampus; MEC
资金
- NIA NIH HHS [AG09973, P01 AG009973-070005, P01 AG009973] Funding Source: Medline
- NIMH NIH HHS [R01 MH052090, P50 MH071702, MH51520, P50 MH071702-01A2, MH52090, R01 MH052090-11A2, MH71702] Funding Source: Medline
It is a consensus that familiarity and recollection contribute to episodic recognition memory. However, it remains controversial whether familiarity and recollection are qualitatively distinct processes supported by different brain regions, or whether they reflect different strengths of the same process and share the same support. In this review, I discuss how adapting standard human recognition memory paradigms to rats, performing circumscribed brain lesions and using receiver operating characteristic (ROC) methods contributed to solve this controversy. First, I describe the validation of the animal ROC paradigms and report evidence that familiarity and recollection are distinct processes in intact rats Second, I report results from rats with hippocampal dysfunction which confirm this finding and lead to the conclusion that the hippocampus supports recollection but not familiarity Finally. I describe a recent study focusing on the medial entorhinal cortex (MEC) that investigates the contribution of areas upstream of the hippocampus to recollection and familiarity (C) 2010 Elsevier Inc All rights reserved.
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