期刊
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
卷 91, 期 9, 页码 1094-1102出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0412.2012.01472.x
关键词
Analgesics; ovarian cancer; histological types; case-control study; gyne-oncology
资金
- National Cancer Institute [RO1 CA 61107]
- Danish Cancer Society
Objective. The role of analgesic drug use in development of ovarian cancer is not fully understood. We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types. Design. Population-based casecontrol study. Setting. Denmark in the period 19951999. Population. We included 756 women with epithelial ovarian cancer and 1564 randomly selected control women aged 3579 years. Methods. Information on analgesic drug use was collected from personal interviews. Analgesic drugs were divided into the following categories: any analgesics; aspirin; non-aspirin non-steroidal anti-inflammatory drugs; paracetamol; and other analgesic drugs. The association between analgesic drug use and ovarian cancer risk was analysed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Main outcome measures. Epithelial ovarian cancer. Results. Women with a regular use of any analgesics (OR = 0.79; 95% CI 0.62 - 1.01) or aspirin (OR = 0.68; 95% CI 0.46 - 1.02) had a decreased risk of ovarian cancer, although not statistically significant. Regular use of non-aspirin non-steroidal anti-inflammatory drugs, paracetamol or other analgesics did not decrease ovarian cancer risk. Use of any analgesics (OR = 0.72; 95% CI 0.530.98) or aspirin (OR = 0.60; 95% CI 0.361.00) resulted in a statistically significant decreased risk of serous ovarian cancer but not mucinous or other ovarian tumors. Conclusion. In accordance with most previous studies, our results indicate a possible inverse association between analgesic use, particularly aspirin, and ovarian cancer risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据