相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex
Stephen Arold et al.
ACTA NEUROPATHOLOGICA (2012)
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β
Robert M. Koffie et al.
BRAIN (2012)
The role of astrocytes in amyloid β-protein toxicity and clearance
Dietmar Rudolf Thal
EXPERIMENTAL NEUROLOGY (2012)
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
Natalia N. Nalivaeva et al.
JOURNAL OF NEUROCHEMISTRY (2012)
LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β
Takahisa Kanekiyo et al.
JOURNAL OF NEUROSCIENCE (2012)
Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex
Sophie Sokolow et al.
NEUROBIOLOGY OF DISEASE (2012)
Overlapping profiles of A beta peptides in the Alzheimer's disease and pathological aging brains
Brenda D. Moore et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
Longitudinal Assessment of A beta and Cognition in Aging and Alzheimer Disease
Victor L. Villemagne et al.
ANNALS OF NEUROLOGY (2011)
FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing
Jaehong Suh et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Opposing Synaptic Regulation of Amyloid-β Metabolism by NMDA Receptors In Vivo
Deborah K. Verges et al.
JOURNAL OF NEUROSCIENCE (2011)
Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis
Jungsu Kim et al.
JOURNAL OF NEUROSCIENCE (2011)
Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake
Takahisa Kanekiyo et al.
JOURNAL OF NEUROSCIENCE (2011)
Alzheimer's disease: synapses gone cold
Robert M. Koffie et al.
MOLECULAR NEURODEGENERATION (2011)
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Adam W. Bero et al.
NATURE NEUROSCIENCE (2011)
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
P. M. Sullivan et al.
NEUROBIOLOGY OF AGING (2011)
Plasma apolipoprotein E and Alzheimer disease risk The AIBL study of aging
V. B. Gupta et al.
NEUROLOGY (2011)
APOE Predicts Amyloid-Beta but Not Tau Alzheimer Pathology in Cognitively Normal Aging
John C. Morris et al.
ANNALS OF NEUROLOGY (2010)
Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
Clifford R. Jack et al.
BRAIN (2010)
Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
Paramita Chakrabarty et al.
FASEB JOURNAL (2010)
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Clifford R. Jack et al.
LANCET NEUROLOGY (2010)
The secretases: enzymes with therapeutic potential in Alzheimer disease
Bart De Strooper et al.
NATURE REVIEWS NEUROLOGY (2010)
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking
Rodrigo A. Fuentealba et al.
PLOS ONE (2010)
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition
Andrei G. Vlassenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types
Victor L. Villemagne et al.
ARCHIVES OF NEUROLOGY (2009)
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease
Clifford R. Jack et al.
BRAIN (2009)
Low-Density Lipoprotein Receptors Regulate Microglial Inflammation Through C-Jun N-Terminal Kinase
Ana Pocivavsek et al.
GLIA (2009)
Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice
William J. Meilandt et al.
JOURNAL OF NEUROSCIENCE (2009)
Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Kelly R. Bales et al.
JOURNAL OF NEUROSCIENCE (2009)
Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
Anthony DelleDonne et al.
MOLECULAR NEURODEGENERATION (2009)
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Guojun Bu
NATURE REVIEWS NEUROSCIENCE (2009)
Conversion of amyloid positive and negative MCI to AD over 3 years An 11C-PIB PET study
A. Okello et al.
NEUROLOGY (2009)
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Eric M. Reiman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Robert M. Koffie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Amyloid Precursor Protein Trafficking, Processing, and Function
Gopal Thinakaran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
David R. Riddell et al.
JOURNAL OF NEUROSCIENCE (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
ApoE promotes the proteolytic degradation of Aβ
Qingguang Jiang et al.
NEURON (2008)
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
William E. Klunk et al.
JOURNAL OF NEUROSCIENCE (2007)
Regulation of steady-state β-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
Elizabeth A. Eckman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
ApoE plasma levels and risk of cardiovascular mortality in old age
Simon P. Mooijaart et al.
PLOS MEDICINE (2006)
Synaptic activity regulates interstitial fluid amyloid-β levels in vivo
JR Cirrito et al.
NEURON (2005)
Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
RL Buckner et al.
JOURNAL OF NEUROSCIENCE (2005)
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
M Koistinaho et al.
NATURE MEDICINE (2004)
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice
P May et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
MA Leissring et al.
NEURON (2003)
Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo
BC Miller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease
AH Moore et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
The importance of plasma concentration in addition apolipoprotein E to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
N Haddy et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2002)
Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology
RH Takahashi et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
DR Thal et al.
NEUROLOGY (2002)
Immunohistochemical localization of neprilysin in the human cerebral cortex:: inverse association with vulnerability to amyloid β-protein (Aβ) deposition
H Akiyama et al.
BRAIN RESEARCH (2001)
Metabolic regulation of brain Aβ by neprilysin
N Iwata et al.
SCIENCE (2001)
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
M Shibata et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)