期刊
ACTA NEUROPATHOLOGICA
卷 115, 期 6, 页码 697-700出版社
SPRINGER
DOI: 10.1007/s00401-008-0341-y
关键词
granule cell dispersion; hippocampal sclerosis; balloon cells; CD34
资金
- MRC [G0600934] Funding Source: UKRI
- Medical Research Council [G0600934] Funding Source: Medline
Granule cell dispersion (GCD) is a common finding in hippocampal sclerosis in patients with intractable focal epilepsy. It is considered to be an acquired, post-developmental rather than a pre-existing abnormality, involving dispersion of either mature or newborn neurones, but the precise factors regulating it and its relationship to seizures are unknown. We present two cases of GCD with associated CD34-immunopositive balloon cells, a cell phenotype associated with focal cortical dysplasia type IIB, considered to be a developmental cortical lesion promoting epilepsy. This observation opens up the debate regarding the origin of balloon cells and CD34 expression and their temporal relationship to seizures.
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