期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 125, 期 6, 页码 373-381出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0404.2011.01576.x
关键词
crossed cerebellar diaschisis; stroke; positron emission tomography; clinical stroke scales; cerebral blood flow; cerebral glucose metabolic rate; imaging surrogate
资金
- Gedeon Richter Chemical Works Plc., Budapest
Background -A common consequence of unilateral stroke is crossed cerebellar diaschisis (CCD), a decrease in regional blood flow (CBF) and metabolism (CMRglu) in the cerebellar hemisphere contralateral to the affected cerebral hemisphere. Former studies indicated a poststroke time-dependent relationship between the degree of CCD and the clinical status of acute and sub-acute stroke patients, but no study has been performed in post-stroke patients. Objectives -The objective of this investigation was to evaluate the quantitative correlation between the degree of CCD and the values of clinical stroke scales in poststroke patients. Materials and Methods -We measured with positron emission tomography (PET) regional CBF and CMRglu values in the affected cortical regions and the contralateral cerebellum in ten ischaemic post-stroke patients. Based on these quantitative parameters, the degree of diaschisis (DoD) was calculated, and the DoD values were correlated with three clinical stroke scales [ Barthel Index, Orgogozo Scale and Scandinavian Neurological Scale (SNS)]. Results -There were significant linear correlations between all clinical stroke scales and the CCD values (Barthel Index and Orgogozo Scale: P < 0.001, for both CBF and CMRglu; SNS: P = 0.007 and P = 0.044; CBF and CMRglu, respectively). Conclusions -The findings indicate that DoD can be used as a quantitative indicator of the functional impairments following stroke, i. e. it can serve as a potential surrogate of the severity of the damage.
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