期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 126, 期 1, 页码 23-31出版社
WILEY
DOI: 10.1111/j.1600-0404.2011.01590.x
关键词
complications; craniotomy; intracranial tumor; metastasis; neoplasm; surgical mortality; survival
Rogne SG, R Phi nning P, Helseth E, Johannesen TB, Langberg CW, Lote K, Scheie D, Meling TR. Craniotomy for brain metastases: a consecutive series of 316 patients.?Acta Neurol Scand: 2012: 126: 2331.?(c) 2011 John Wiley & Sons A/S. Objective To assess the incidence of craniotomy for brain metastases, overall survival (OS), surgical mortality, and prognostic factors in a large, contemporary, consecutive series from a well-defined catchment area. Material and methods All patients =18 years who underwent craniotomies for intracranial metastases at Oslo University Hospital, Rikshospitalet and Ulleval, between 2005 and June 30, 2009 were included (n = 316). Patients were identified from our prospectively collected database and a thorough review of all charts to validate the entered data was performed. Results The annual incidence of first-time craniotomy for a brain metastasis was 2.6/100,000 inhabitants. Patient age ranged from 25 to 87 years (median 64 years). The 30-day mortality rate was 3.8%. Median OS was 9.2 months. Recursive partitioning analysis was class I in 19.6%, class II in 59.2%, and class III in 21.2% with median OS of 16.2, 8.9, and 5.6 months, respectively (P < 0.001). Lung cancer and melanoma were associated with a higher risk (>1% per year) of developing brain metastases. Significant negative prognostic factors were age =65, a poor performance score, unstable extracranial disease, presence of extracranial metastases, multiplicity, metastasis in eloquent area, and no post-operative radiotherapy. Conclusions In this population study, the annual incidence of a first-time craniotomy for a brain metastasis was 2.6/100,000, the 30-day mortality rate was 3.8%, and median OS was 9.2 months. The well-known prognostic factors were confirmed.
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